If the “Two-Sided” drop-down menu is greyed out, your printer may not support double-sided printing.

“Long-edge binding” is what is most commonly used. Select this option if you plan on binding your pages by the long edges of the paper. This would be the left and right edges if you are printing using portrait orientation. Select “Short-edge binding” if you plan of binding your pages by the short edges of the paper. This would be the top and bottoms of the pages using portrait orientation, or the left and right using landscape orientation.