Draining the pus can relieve the pressure and reduce pain. Keep in mind that you’ll need to monitor the blister and keep it bandaged and clean after you drain it.

You should also disinfect a needle by swabbing it with the rubbing alcohol or iodine solution or holding it in a flame for about a minute.

You might want to take a cotton ball or piece of gauze to dab or wipe up the fluid or pus that leaks out of the blister. Wash the infected area out with either hydrogen peroxide, saline or soap and water. Do not use alcohol or iodine as they will irritate the wound.

Always wash your hands before and after you change the dressing. Remove the dressing daily before bathing, and allow the water to clean it out in the shower. Pat it dry after the shower and reapply the bandage.

Garlic has natural antibiotic properties which can kill bacteria or viruses that could be infecting your blister. [5] X Research source

Aloe contains natural anti-inflammatory and antibiotic substances that may help treat the infected blister while moisturizing the skin. [6] X Research source Hamid Nasri, Mahmoud Bahmani, Najmeh Shahinfard, Atefeh Moradi Nafchi, Shirin Saberianpour, Mahmoud Rafieian Kopaei, Medicinal Plants for the Treatment of Acne Vulgaris: A Review of Recent Evidences. Jundishapur J Microbiol. 2015 November; 8(11): e25580.

Tea tree oil has antibacterial, antimicrobial and anti-inflammatory properties. More research is needed to determine how effective tea tree oil is against bacterial, fungal and viral infections. [7] X Trustworthy Source PubMed Central Journal archive from the U. S. National Institutes of Health Go to source

If you can find mullein,[9] X Trustworthy Source PubMed Central Journal archive from the U. S. National Institutes of Health Go to source yarrow or plantain outside, take a few leaves (or flowers from mullein) and crush them into a paste. Add a few drops of castor oil if you need to make the paste easier to spread. Apply the paste directly to the blister. These plants have antibiotic and anti-inflammatory properties. [10] X Research source

If you see reddish streaks along your skin starting at or around the blister or if you have persistent drainage, pain around the blister, or a fever, you might have a more serious infection (like lymphangitis). [12] X Research source If this happens, make sure to call your physician for advice.

Avoid breaking the skin of your blister. Never rub the blister when washing or drying.

Even moist skin can create friction and aggravate your blister. You may want to sprinkle aluminum chloride or talcum powder on the skin around your blister to keep the skin completely dry. [15] X Trustworthy Source Cleveland Clinic Educational website from one of the world’s leading hospitals Go to source

Pemphigus: a chronic skin disease Bullous pemphigoid: an autoimmune skin disease Dermatitis herpetiformis: a chronic skin rash